Cofactor Binding Evokes Latent Differences in DNA Binding Specificity between Hox Proteins
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چکیده
منابع مشابه
Cofactor Binding Evokes Latent Differences in DNA Binding Specificity between Hox Proteins
Members of transcription factor families typically have similar DNA binding specificities yet execute unique functions in vivo. Transcription factors often bind DNA as multiprotein complexes, raising the possibility that complex formation might modify their DNA binding specificities. To test this hypothesis, we developed an experimental and computational platform, SELEX-seq, that can be used to...
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ژورنال
عنوان ژورنال: Cell
سال: 2011
ISSN: 0092-8674
DOI: 10.1016/j.cell.2011.10.053